Please use this identifier to cite or link to this item: https://hdl.handle.net/1/1237
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dc.contributor.authorBack, Michael-
dc.contributor.authorEade, Thomas-
dc.contributor.otherMcKelvey, K.J.-
dc.contributor.otherHudson, A.L.-
dc.contributor.otherDiakos, C.I.-
dc.date.accessioned2018-12-12T01:03:53Zen
dc.date.available2018-12-12T01:03:53Zen
dc.date.issued2018-09-
dc.identifier.citation29(11-12):843-865en
dc.identifier.issn0938-8990en
dc.identifier.urihttps://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/1237en
dc.description.abstractRadiation is an important component of cancer treatment with more than half of all patients receive radiotherapy during their cancer experience. While the impact of radiation on tumour morphology is routinely examined in the pre-clinical and clinical setting, the impact of radiation on the tumour microenvironment and more specifically the inflammatory/immune response is less well characterised. Inflammation is a key contributor to short- and long-term cancer eradication, with significant tumour and normal tissue consequences. Therefore, the role of radiation in modulating the inflammatory response is highly topical given the current wave of targeted and immuno-therapeutic treatments for cancer. This review provides a general overview of how radiation modulates the inflammatory and immune response-(i) how radiation induces the inflammatory/immune system, (ii) the cellular changes that take place, (iii) how radiation dose delivery affects the immune response, and (iv) a discussion on research directions to improve patient survival, reduce side effects, improve quality of life, and reduce financial costs in the immediate future. Harnessing the benefits of radiation on the immune response will enhance its maximal therapeutic benefit and reduce radiation-induced toxicity.en
dc.description.sponsorshipRadiation Oncologyen
dc.description.sponsorshipCentral Coast Cancer Centreen
dc.subjectRadiation Therapyen
dc.subjectCanceren
dc.subjectRadiotherapyen
dc.titleRadiation, inflammation and the immune response in canceren
dc.typeJournal Articleen
dc.identifier.doi10.1007/s00335-018-9777-0en
dc.description.pubmedurihttps://www.ncbi.nlm.nih.gov/pubmed/30178305en
dc.description.affiliatesCentral Coast Local Health Districten
dc.description.affiliatesGosford Hospitalen
dc.identifier.journaltitleMammalian Genome : Official Journal of the International Mammalian Genome Societyen
dc.relation.orcidhttp://orcid.org/0000-0003-2363-8333en
dc.originaltypeTexten
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
crisitem.author.deptRadiation Oncology-
Appears in Collections:Oncology / Cancer
Radiology
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