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dc.contributor.authorSturm, Jonathanen
dc.contributor.authorCrimmins, Denisen
dc.contributor.authorWhyte, Scotten
dc.contributor.otherTownend, Bradleyen
dc.contributor.otherDesborough, T.en
dc.contributor.otherMarkus, R.en
dc.contributor.otherLevi, C.R.en
dc.identifier.citationVolume 14, Issue 5, pp. 429 - 434en
dc.description.abstractBACKGROUND: Early identification of mood disorder post-stroke (MDPS) or its determinants could improve stroke outcomes. However, the natural history, prevalence and determinants of MDPS within the first weeks post-stroke require further investigation. METHODS: Consecutive hospitalised stroke survivors were assessed within 2-5 days of stroke, and at 1 and 3 months post-stroke. Baseline data included demographics, co-morbidities, stroke subtype, pre-stroke disability and cognition. At baseline, 1- and 3-month interviews physical impairment, disability, cognition and social support were assessed. MDPS was defined as a score of >8 on the depression subscale of the Hospital Anxiety Depression Scale. Factors independently associated with MDPS at each time-point were determined using regression analyses. RESULTS: One hundred and twenty-five subjects were included. The prevalence of MDPS within 5 days and at 1 and 3 months post-stroke was 5%, 16% and 21% respectively. The independent determinants for MDPS at 1 month were disability, social support and change in impairment score between initial and 1-month assessments; and at 3 months were disability, social support and institutionalisation. Individuals moved in and out of the subset of depressed patients over time. MDPS was independently associated with mortality at 3 months post-stroke. CONCLUSION: Mood disorder post-stroke increases in prevalence over the initial weeks post-stroke despite an improvement in disability, and is associated with mortality. Patients with MDPS at 1 month were not necessarily affected at 3 months and vice versa, indicating the dynamic nature of MDPS in the early stages.en
dc.titleLongitudinal prevalence and determinants of early mood disorder post-strokeen
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Clinical Neuroscience : official journal of the Neurosurgical Society of Australasiaen
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
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