Please use this identifier to cite or link to this item: https://hdl.handle.net/1/1710
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dc.contributor.authorEvans, James W-
dc.contributor.otherGensicke, H.-
dc.contributor.otherAl-Ajlan, F.S.-
dc.contributor.otherDowlatshahi, D.-
dc.contributor.otherNajm, M.-
dc.contributor.otherCalleja, A.L.-
dc.contributor.otherPuig, J.-
dc.contributor.otherSohn, S.L.-
dc.contributor.otherAhn, S.H.-
dc.contributor.otherPoppe, A.Y.-
dc.contributor.otherMikulik, R.-
dc.contributor.otherAsdaghi, N.-
dc.contributor.otherField, T.S.-
dc.contributor.otherJin, A.-
dc.contributor.otherAsil, T.-
dc.contributor.otherBoulanger, J.M.-
dc.contributor.otherHill, M.D.-
dc.contributor.otherGoyal, M.-
dc.contributor.otherDemchuk, A.M.-
dc.contributor.otherMenon, B.K.-
dc.date.accessioned2019-12-02T00:11:54Z-
dc.date.available2019-12-02T00:11:54Z-
dc.date.issued2019-11-
dc.identifier.citation62(3):301-306en
dc.identifier.issn0028-3940en
dc.identifier.urihttps://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/1710-
dc.description.abstractPURPOSE: To compare the association of different measures of intracranial thrombus permeability on non-contrast computerized tomography (NCCT) and computed tomography angiography (CTA) with recanalization with or without intravenous alteplase. METHODS: Patients with anterior circulation occlusion from the INTERRSeCT study were included. Thrombus permeability was measured on non-contrast CT and CTA using the following methods: [1] automated method, mean attenuation increase on co-registered thin (< 2.5 mm) CTA/NCCT; [2] semi-automated method, maximum attenuation increase on non-registered CTA/NCCT (DeltaHUmax); [3] manual method, maximum attenuation on CTA (HUmax); and [4] visual method, residual flow grade. Primary outcome was recanalization with intravenous alteplase on the revised AOL scale (2b/3). Regression models were compared using C-statistic, Akaike (AIC), and Bayesian information criterion (BIC). RESULTS: Four hundred eighty patients were included in this analysis. Statistical models using methods 2, 3, and 4 were similar in their ability to discriminate recanalizers from non-recanalizers (C-statistic 0.667, 0.683, and 0.634, respectively); method 3 had the least information loss (AIC = 483.8; BIC = 492.2). A HUmax >/= 89 measured with method 3 provided optimal sensitivity and specificity in discriminating recanalizers from non-recanalizers [recanalization 55.4% (95%CI 46.2-64.6) when HUmax > 89 vs. 16.8% (95%CI 13.0-20.6) when HUmax </= 89]. In sensitivity analyses restricted to patients with co-registered CTA/NCCT (n = 88), methods 1-4 predicted recanalization similarly (C-statistic 0.641, 0.688, 0.640, 0.648, respectively) with Method 2 having the least information loss (AIC 104.8, BIC 109.8). CONCLUSION: Simple methods that measure thrombus permeability are as reliable as complex image processing methods in discriminating recanalizers from non-recanalizers.en
dc.description.sponsorshipNeuroscienceen
dc.subjectNeurologyen
dc.subjectStrokeen
dc.titleComparison of different methods of thrombus permeability measurement and impact on recanalization in the INTERRSeCT multinational multicenter prospective cohort studyen
dc.typeJournal Articleen
dc.identifier.doi10.1007/s00234-019-02320-yen
dc.description.pubmedurihttps://www.ncbi.nlm.nih.gov/pubmed/31713667en
dc.description.affiliatesCentral Coast Local Health Districten
dc.description.affiliatesGosford Hospitalen
dc.identifier.journaltitleNeuroradiologyen
dc.type.studyortrialProspective Cohort Studyen
dc.originaltypeTexten
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
Appears in Collections:Neurology
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