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Title: Clinical utility of ramucirumab in advanced gastric cancer
Authors: Chan, Matthew M K ;Sjoquist, K.M.;Zalcberg, J.R.
Issue Date: Sep-2015
Source: 2015:9, pp. 93 - 105
Journal title: Biologics: Targets and Therapy
Abstract: Gastric cancer is currently the third most common cause of cancer deaths worldwide. Prognosis remains poor with most patients presenting with advanced or metastatic disease. A better understanding of angiogenesis has led to the investigation of drugs that inhibit the vascular endothelial growth factor (VEGF) pathway including anti-VEGF antibody therapy (eg, bevacizumab), inhibitors of angiogenic receptor tyrosine kinases (eg, sunitinib, sorafenib, apatinib, regorafenib), and inhibitors of vascular endothelial growth factor receptors (VEGFRs) (eg, ramucirumab). Ramucirumab, a VEGFR-2 inhibitor, is the first anti-angiogenic agent approved by the US Food and Drug Administration for use in the treatment of advanced gastric cancers. This review will focus on the clinical utility and potential use of ramucirumab in advanced gastric cancer.
DOI: 10.2147/btt.S62777
ISSN: 1177-5475
Publicaton type: Journal Article
Keywords: Cancer
Drug Therapy
Study or Trial: Reviews/Systematic Reviews
Appears in Collections:Oncology / Cancer

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