Please use this identifier to cite or link to this item: https://hdl.handle.net/1/1996
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dc.contributor.authorRogers, James-
dc.contributor.authorForsyth, Cecily J-
dc.contributor.authorFord, Tom-
dc.contributor.authorMikhail, Philopatir-
dc.date.accessioned2021-09-07T02:00:04Z-
dc.date.available2021-09-07T02:00:04Z-
dc.date.issued2021-07-
dc.identifier.citation5(7):ytab076en
dc.identifier.issn2514-2119en
dc.identifier.urihttps://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/1996-
dc.description.abstractBACKGROUND: Coronary vasospasm is an increasingly recognized cause of myocardial infarction or myocardial ischaemia in patients without obstructive coronary artery disease. A thorough medication review may identify drugs or toxins that could trigger coronary vasospasm. This case provides mechanistic insight into the off-target effect of proteasome inhibition leading to coronary vasospasm in a patient referred with chest pain consistent with typical angina. CASE SUMMARY: A 72-year-old lady presented with anginal chest pain at rest with electrocardiogram evidence of myocardial ischaemia who was referred for invasive coronary angiography. This demonstrated minor coronary disease without an obstructive lesion. Vasoreactivity testing revealed diffuse coronary vasospasm of the left anterior descending artery. Carfilzomib was identified as the trigger for coronary vasospasm. Symptoms resolved without recurrence after appropriate treatment including cessation of the triggering agent. CONCLUSION: Coronary spasm is a rare but important adverse reaction to proteasome inhibitors. This case supports the clinical utility of invasive coronary vasoreactivity testing in patients with ischaemia with no obstructive coronary artery disease.en
dc.description.sponsorshipCardiologyen
dc.description.sponsorshipHaematologyen
dc.subjectCardiologyen
dc.titleProteasome inhibitor-induced coronary vasospasm in multiple myeloma: A case reporten
dc.typeJournal Articleen
dc.identifier.doi10.1093/ehjcr/ytab076en
dc.description.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/34345762/en
dc.description.affiliatesCentral Coast Local Health Districten
dc.description.affiliatesGosford Hospitalen
dc.description.affiliatesThe University of Newcastleen
dc.identifier.journaltitleEuropean heart journal. Case reportsen
dc.type.studyortrialCase Series and Case Reportsen
dc.relation.orcidhttps://orcid.org/0000-0002-9108-3088en
dc.relation.orcidhttps://orcid.org/0000-0003-4009-6652en
dc.originaltypeTexten
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
crisitem.author.deptHaematology-
Appears in Collections:Cardiology
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