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https://hdl.handle.net/1/2281
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DC Field | Value | Language |
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dc.contributor.author | Ford, Tom | - |
dc.contributor.author | Adamson, Carly | - |
dc.contributor.author | Morrow, Andrew J | - |
dc.contributor.author | Rocchiccioli, Paul | - |
dc.contributor.author | Collison, Damien | - |
dc.contributor.author | McCartney, Peter J | - |
dc.contributor.author | Shaukat, Aadil | - |
dc.contributor.author | Lindsay, Mitchell | - |
dc.contributor.author | Good, Richard | - |
dc.contributor.author | Watkins, Stuart | - |
dc.contributor.author | Eteiba, Hany | - |
dc.contributor.author | Robertson, Keith | - |
dc.contributor.author | Berry, Colin | - |
dc.contributor.author | Oldroyd, Keith G | - |
dc.contributor.author | McEntegart, Margaret | - |
dc.date.accessioned | 2022-12-18T23:21:39Z | - |
dc.date.available | 2022-12-18T23:21:39Z | - |
dc.date.issued | 2022-10-04 | - |
dc.identifier.citation | 11(19):e024492 | en |
dc.identifier.uri | https://hdl.handle.net/1/2281 | - |
dc.description.abstract | Background The objective of the GNOCCI (Glasgow Natural History Study of Covered Stent Coronary Interventions) Study was to report the incidence and outcomes of coronary artery perforations over an 18-year period at a single, high-volume percutaneous coronary intervention center. We considered both the temporal trends and long-term outcomes of covered stent deployment. Methods and Results We evaluated procedural and long-term clinical outcomes following coronary perforation in a cohort of 43,343 consecutive percutaneous coronary intervention procedures. Procedural major adverse cardiac events were defined as a composite of death, myocardial infarction, stroke, target vessel revascularization, or cardiac surgery within 24 hours. A total of 161 (0.37%) procedures were complicated by coronary perforation of which 57 (35%) were Ellis grade III. Incidence increased with time over the study period (r=0.73; P<0.001). Perforation severity was linearly associated with procedural mortality (median 2.9-year follow-up): Ellis I (0%), Ellis II (1.7%), Ellis III/IIIB (21%), P<0.001. Procedural major adverse cardiac events occurred in 47% of patients with Ellis III/IIIB versus 13.5% of those with Ellis I/II perforations (odds ratio, 5.8; 95% CI, 2.7-12.5; P<0.001). Covered stents were associated with an increased risk of stent thrombosis at 2.9-year follow-up (Academic Research Consortium definite or probable; 9.1% versus 0.9%; risk ratio, 10.5; 95% CI, 1.1-97; P=0.04). Conclusions The incidence of coronary perforation increased between 2001 and 2019. Severe perforation was associated with higher procedural major adverse cardiac events and was an independent predictor of long-term mortality. Although covered stents are a potentially lifesaving treatment, the generation of devices used during the study period was limited by their efficacy and high risk of stent thrombosis. Registration Information Clinicaltrials.gov. Identifier: NCT03862352. | en |
dc.description.sponsorship | Cardiology | en |
dc.subject | Cardiology | en |
dc.subject | Heart Disease | en |
dc.subject | Cardiovascular Disease | en |
dc.title | Coronary Artery Perforations: Glasgow Natural History Study of Covered Stent Coronary Interventions (GNOCCI) Study | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1161/JAHA.121.024492 | en |
dc.description.pubmeduri | https://pubmed.ncbi.nlm.nih.gov/36129052/ | en |
dc.description.affiliates | Central Coast Local Health District | en |
dc.description.affiliates | Gosford Hospital | en |
dc.identifier.journaltitle | Journal of the American Heart Association | en |
item.grantfulltext | none | - |
item.openairetype | Journal Article | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Cardiology | - |
Appears in Collections: | Cardiology |
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