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Title: Importance of sequential methods in meta-analysis: implications for postoperative mortality, delirium, and stroke management
Authors: Payne, Thomas;Moran, Benjamin L ;Loadsman, John;Marschner, Ian;McCulloch, Tim;Sanders, Robert D
Affliation: Central Coast Local Health District
Gosford Hospital
Issue Date: Apr-2023
Source: 130(4):395-401.
Journal title: British Journal of Anaesthesia
Department: Health Promotion
Abstract: Trial sequential analysis is an adaptation of frequentist sequential methods that can be used to improve inferences from meta-analysis. Trial sequential analysis can help preserve type I and type II error rates at desired levels for analyses conducted before the required information size. Through three case studies recently published in the British Journal of Anaesthesia, we show how trial sequential analysis can inform the interpretation of meta-analyses. Limitations of trial sequential analysis, which also include those of the meta-analysis to which it is applied, must be carefully considered alongside its benefits.
DOI: 10.1016/j.bja.2023.01.011
Publicaton type: Journal Article
Keywords: Stroke
Appears in Collections:Health Service Research

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