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dc.contributor.authorToto, Roberten
dc.contributor.authorPichette, Vincenten
dc.contributor.authorNavarro, Jesusen
dc.contributor.authorBrenner, Roberten
dc.contributor.authorCarroll, Wendien
dc.contributor.authorLiu, Weien
dc.contributor.authorRoger, Simon Den
dc.identifier.citationVolume 24, Issue 4, pp. 453-460en
dc.description.abstractAIM: This multicenter, open-label study determined safety and efficacy of once-every-other-week administration of darbepoetin alfa for anemia of chronic kidney disease in erythropoietin-naive patients not on dialysis. METHODS: Participants with hemoglobin levels <11.0 g/dl at baseline were administered darbepoetin alfa at an initial dosage of 0.75 microg/kg once every other week. The dose was titrated to achieve and maintain a hemoglobin response, defined as a hemoglobin range of between 11.0 and 13.0 g/dl for up to 24 weeks. The primary end point was the dose of darbepoetin alfa at initial hemoglobin response. RESULTS: Six hundred and eight patients were enrolled, and 463 completed the study; 95% (95% confidence interval: 0.93, 0.97) of the patients who completed treatment achieved a hemoglobin response. The mean darbepoetin alfa dose at the time of response was 63.5 +/- (SD) 16.9 microg, and the mean time to hemoglobin response was 5.7 +/- (SD) 4.5 weeks. Oral iron therapy was administered to 60% and intravenous iron to 16% of the participants. Darbepoetin alfa was well tolerated, and adverse events were consistent with those expected in patients with chronic kidney disease. CONCLUSION: Darbepoetin alfa administered once every other week is effective and safe for achieving and maintaining target hemoglobin levels in anemic patients with chronic kidney disease.en
dc.subjectKidney Diseaseen
dc.titleDarbepoetin Alfa effectively treats Anemia in patients with chronic kidney disease with De Novo Every-Other-Week administrationen
dc.typeJournal Articleen
dc.identifier.journaltitleAmerican Journal of Nephrologyen
dc.type.studyortrialMulticentre Studiesen
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
Appears in Collections:Renal Medicine
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