Please use this identifier to cite or link to this item: https://hdl.handle.net/1/2706
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dc.contributor.authorBland, Adam-
dc.contributor.authorMeere, William-
dc.contributor.authorMikhail, Philopatir-
dc.contributor.authorChuah, Eunice-
dc.contributor.authorRedwood, Eleanor-
dc.contributor.authorFerreira, David-
dc.contributor.authorHowden, Nicklas-
dc.contributor.authorPerkovic, Adam-
dc.contributor.authorSaunders, Samantha-
dc.contributor.authorKelty, Amy-
dc.contributor.authorKull, Anthony-
dc.contributor.authorHill, Andrew-
dc.contributor.authorSpina, Roberto-
dc.contributor.authorSarathy, Kiran-
dc.contributor.authorMay, Austin N-
dc.contributor.authorParkinson, Michael-
dc.contributor.authorIshak, Mark-
dc.contributor.authorCollins, Nicholas-
dc.contributor.authorBoyle, Andrew-
dc.contributor.authorWilliam, Maged-
dc.contributor.authorJeyaprakashk, Prajith-
dc.contributor.authorFord, Tom-
dc.date.accessioned2024-09-04T01:46:06Z-
dc.date.available2024-09-04T01:46:06Z-
dc.date.issued2024-08-31-
dc.identifier.citationOnline ahead of printen
dc.identifier.urihttps://hdl.handle.net/1/2706-
dc.description.abstractBackground: The 1.5mm 'Baby J' hydrophilic narrow J tipped wire is a development of the standard 0.035" 3mm J tipped peripheral guidewire, designed to improve efficiency of transradial coronary procedures by safely navigating small caliber radial arteries to the aorta. There is currently a lack of evidence comparing the procedural success and safety of different peripheral guidewires used in transradial cardiac procedures. We compared the efficacy and safety of a narrow J tipped hydrophilic 0.035" wire (intervention - Radifocus™ 'Baby J' guidewire, TERUMO Co., Tokyo, Japan). versus standard fixed core (FC) 0.035" J wire (control). Methods: Investigator initiated, blinded, Australian, multicenter randomized trial in patients undergoing clinically indicated coronary angiography and/or PCI. Randomized 1:1 via sealed envelope method to use either the control or the intervention guidewire. The primary endpoint (technical success) was defined as gaining aortic root access with the randomized guidewire. Results: 330 patients were randomized between October 2022 - June 2023 (median age 69 years, 36% female, BMI 29 kg/m²). The primary endpoint was achieved more frequently in the intervention group [96% v 84%; mean difference 12% (95% CI 5.7-18.3); p<0.001]. Women assigned to the control wire experienced a higher failure rate compared to men (31% v 8% in men; p<0.001). Fluoroscopy time was significantly shorter in the baby J group (median 344 versus 491 seconds; p=0.024). The main mechanisms of failure using the control wire were radial artery spasm (15/26; 57%) and subclavian tortuosity (5/26; 19.2%). There were no differences in overall procedure times, MACE, or vascular complications between guidewires. Conclusions: A narrow 1.5mm J tipped hydrophilic guidewire resulted in greater technical success and reduced fluoroscopy time compared to the standard 3mm J tip non-hydrophilic guidewire. The guidewire is safe and demonstrated key incremental benefits for the trans-radial approach particularly in women.en
dc.description.sponsorshipCardiologyen
dc.subjectCardiologyen
dc.subjectCardiovascular Diseaseen
dc.titleEnhancing Guidewire Efficacy for Trans-radial Access: The EAGER Randomized Controlled Trialen
dc.typeJournal Articleen
dc.description.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/39215512en
dc.description.affiliatesCentral Coast Local Health Districten
dc.description.affiliatesGosford Hospitalen
dc.identifier.journaltitleCirculation. Cardiovascular Interventionsen
dc.type.studyortrialRandomized Controlled Clinical Trial/Controlled Clinical Trialen
dc.type.contentTexten
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptCardiology-
crisitem.author.deptCardiology-
crisitem.author.deptObstetrics & Gynaecology-
crisitem.author.deptCardiology-
crisitem.author.deptCardiology-
crisitem.author.deptCardiology-
crisitem.author.deptCardiology-
crisitem.author.deptCardiology-
crisitem.author.deptCardiology-
Appears in Collections:Cardiology
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