Please use this identifier to cite or link to this item: https://hdl.handle.net/1/2790
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dc.contributor.authorThottiyil Sultanmuhammed Abdul Khadar, Bismi-
dc.contributor.authorSim, Jenny-
dc.contributor.authorMcDonald, Vanessa M-
dc.contributor.authorMcDonagh, Julee-
dc.contributor.authorClapham, Matthew-
dc.contributor.authorMitchell, Brett-
dc.date.accessioned2024-11-29T00:21:16Z-
dc.date.available2024-11-29T00:21:16Z-
dc.date.issued2024-11-04-
dc.identifier.citation7(11):e2443769en
dc.identifier.urihttps://hdl.handle.net/1/2790-
dc.description.abstractThe effectiveness of in-room air purification for the reduction of acute respiratory infections (ARIs) in residential aged-care facilities (RACFs) is unknown. To investigate the effectiveness of in-room air purifiers with high-efficiency particulate air (HEPA)-14 filters in reducing the incidence of ARIs among residents of RACFs. This randomized clinical trial used a multicenter, double-blind, 2-period, 2-treatment crossover design for 6 months from April 7 to October 26, 2023, in 3 RACFs with a bed capacity of 50 to 100 in New South Wales, Australia. The purposive sampling approach included permanent residents in private rooms in the enrolled RACFs. Data collection was performed every 2 weeks and required no additional follow-up beyond the final data collection on October 31, 2023. An air purifier containing a HEPA-14 filter was placed in rooms of participants in the intervention group, and an air purifier without a HEPA-14 filter was placed in rooms of the control participants. The groups crossed over after 3 months. The primary outcome was the incidence of ARIs, assessed with logistic mixed-model regression. Among 135 participants randomized (70 to the intervention-first group and 65 to the control-first group), 78 (57.8%) were female; mean (SD) age was 85.2 (8.6) years. In the intention-to-treat analysis, the use of air purifiers with HEPA-14 filters did not reduce ARIs compared with the control (OR, 0.57; 95% CI, 0.32-1.04; P = .07). Among the 104 participants who completed the entire study, the intervention reduced ARI incidence from 35.6% (37 participants) in the control group to 24.0% (25 participants) in the intervention group (OR, 0.53; 95% CI, 0.28-1.00; P = .048). In this clinical trial investigating use of air purifiers with HEPA-14 filters for reducing ARIs, no significant between-group difference was found in the intention-to-treat analysis. However, a significant reduction in ARIs was identified among participants who completed the entire study. These findings may help inform future large-scale studies of respiratory infectious diseases. ANZCTR identification: ACTRN12623000347662.en
dc.description.sponsorshipNursing & Midwifery Directorateen
dc.subjectInfection Controlen
dc.titleAir Purifiers and Acute Respiratory Infections in Residential Aged Care: A Randomized Clinical Trialen
dc.typeJournal Articleen
dc.identifier.doi10.1001/jamanetworkopen.2024.43769en
dc.description.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/39527057en
dc.description.affiliatesCentral Coast Local Health Districten
dc.description.affiliatesGosford Hospitalen
dc.identifier.journaltitleJAMA Network Openen
dc.type.studyortrialRandomized Controlled Clinical Trial/Controlled Clinical Trialen
dc.type.contentTexten
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
Appears in Collections:Health Service Research
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