Please use this identifier to cite or link to this item: https://hdl.handle.net/1/820
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dc.contributor.authorSturm, Jonathanen
dc.contributor.otherCarey, Leeanne Men
dc.contributor.otherCrewther, Sheilaen
dc.contributor.otherSalvado, Olivieren
dc.contributor.otherLinden, Thomasen
dc.contributor.otherConnelly, Alanen
dc.contributor.otherWilson, Williamen
dc.contributor.otherHowells, David Wen
dc.contributor.otherChurilov, Leoniden
dc.contributor.otherMa, H.en
dc.contributor.otherTse, Tamaraen
dc.contributor.otherRose, Stephenen
dc.contributor.otherPalmer, Susanen
dc.contributor.otherBougeat, Pierricken
dc.contributor.otherCampbell, B.C.en
dc.contributor.otherChristensen, S.en
dc.contributor.otherMacaulay, S. Lanceen
dc.contributor.otherFavaloro, J.en
dc.contributor.otherO'Collins, Victoriaen
dc.contributor.otherMcBride, Simonen
dc.contributor.otherBates, Susanen
dc.contributor.otherCowley, Eliseen
dc.contributor.otherDewey, H.M.en
dc.contributor.otherWijeratne, Tessaen
dc.contributor.otherGerraty, Richarden
dc.contributor.otherPhan, Thanh Gen
dc.contributor.otherYan, Bernarden
dc.contributor.otherParsons, M.W.en
dc.contributor.otherBladin, C.F.en
dc.contributor.otherBarber, P.A.en
dc.contributor.otherRead, Stephenen
dc.contributor.otherWong, Andrewen
dc.contributor.otherLee, Andrewen
dc.contributor.otherKleinig, T.en
dc.contributor.otherHankey, G.J.en
dc.contributor.otherBlacker, Daviden
dc.contributor.otherMarkus, R.en
dc.contributor.otherLeyden, Jamesen
dc.contributor.otherKrause, Martinen
dc.contributor.otherGrimley, Rohanen
dc.contributor.otherMahant, N.en
dc.contributor.otherJannes, J.en
dc.contributor.otherDavis, Stephen Men
dc.contributor.otherDonnan, G.A.en
dc.date.accessioned2016-03-03T05:03:27Zen
dc.date.available2016-03-03T05:03:27Zen
dc.date.issued2015-06en
dc.identifier.citationVolume 10, Issue 4, pp.636-644en
dc.identifier.issn1747-4949en
dc.identifier.urihttps://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/820en
dc.description.abstractRATIONALE: Stroke and poststroke depression are common and have a profound and ongoing impact on an individual's quality of life. However, reliable biological correlates of poststroke depression and functional outcome have not been well established in humans. AIMS: Our aim is to identify biological factors, molecular and imaging, associated with poststroke depression and recovery that may be used to guide more targeted interventions. DESIGN: In a longitudinal cohort study of 200 stroke survivors, the START-STroke imAging pRevention and Treatment cohort, we will examine the relationship between gene expression, regulator proteins, depression, and functional outcome. Stroke survivors will be investigated at baseline, 24h, three-days, three-months, and 12 months poststroke for blood-based biological associates and at days 3-7, three-months, and 12 months for depression and functional outcomes. A sub-group (n=100), the PrePARE: Prediction and Prevention to Achieve optimal Recovery Endpoints after stroke cohort, will also be investigated for functional and structural changes in putative depression-related brain networks and for additional cognition and activity participation outcomes. Stroke severity, diet, and lifestyle factors that may influence depression will be monitored. The impact of depression on stroke outcomes and participation in previous life activities will be quantified. STUDY OUTCOMES: Clinical significance lies in the identification of biological factors associated with functional outcome to guide prevention and inform personalized and targeted treatments. Evidence of associations between depression, gene expression and regulator proteins, functional and structural brain changes, lifestyle and functional outcome will provide new insights for mechanism-based models of poststroke depression.en
dc.subjectStrokeen
dc.subjectNeurologyen
dc.titleSTroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol.en
dc.typeJournal Articleen
dc.identifier.doi10.1111/ijs.12190en
dc.description.pubmedurihttp://www.ncbi.nlm.nih.gov/pubmed/?term=24206623en
dc.description.affiliatesFlorey Institute of Neuroscience and Mental Healthen
dc.description.affiliatesLa Trobe Universityen
dc.description.affiliatesCommonwealth Scientific and Industrial Research Organisation (CSIRO)en
dc.description.affiliatesGothenburg University, Swedenen
dc.description.affiliatesMonash Medical Centreen
dc.description.affiliatesUniversity of Melbourneen
dc.description.affiliatesMelbourne Brain Centreen
dc.description.affiliatesAustin Health, Victoriaen
dc.description.affiliatesWestern Health, Melbourneen
dc.description.affiliatesEpworth Healthcare, Melbourneen
dc.description.affiliatesJohn Hunter Hospital, Newcastle, NSWen
dc.description.affiliatesThe University of Newcastleen
dc.description.affiliatesEastern Health, Melbourneen
dc.description.affiliatesAuckland City Hospital, New Zealanden
dc.description.affiliatesRoyal Brisbane and Women's Hospital, Queenslanden
dc.description.affiliatesFlinders Medical Centre, Adelaideen
dc.description.affiliatesRoyal Adelaide Hospital, South Australiaen
dc.description.affiliatesThe University of Western Australiaen
dc.description.affiliatesSir Charles Gardiner Hospital, Perthen
dc.description.affiliatesSt Vincent's Hospital, Sydneyen
dc.description.affiliatesLyell McEwin Hospital, Adelaideen
dc.description.affiliatesRoyal North Shore Hospital, Sydneyen
dc.description.affiliatesNambour General Hospital, Queenslanden
dc.description.affiliatesWestmead Hospital, Sydneyen
dc.description.affiliatesThe Queen Elizabeth Hospital, South Australiaen
dc.identifier.journaltitleInternational Journal of Strokeen
dc.type.studyortrialCohort Studyen
dc.originaltypeTexten
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
Appears in Collections:Neurology
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