Please use this identifier to cite or link to this item: https://hdl.handle.net/1/1273
Title: Cyclical thrombocytosis, acquired von Willebrand syndrome and aggressive non-melanoma skin cancers are common in patients with Philadelphia-negative myeloproliferative neoplasms treated with hydroxyurea
Authors: Forsyth, Cecily J ;Verner, E.;Grigg, A.
Issue Date: May-2014
Source: Volume 55, Issue 5, pp. 1139 - 1143
Journal title: Leukemia & Lymphoma
Abstract: Abstract Cyclical thrombocytosis, acquired von Willebrand syndrome, aggressive non-melanoma skin cancers and other hydroxyurea complications have been reported in Philadelphia-negative myeloproliferative neoplasms (MPNs), but their incidence and clinical consequences have not been defined in a large cohort of patients. We conducted a retrospective analysis of 188 consecutive patients with MPNs specifically addressing the incidence of these complications. Cyclical thrombocytosis was documented in 29 patients (15%), the majority of whom were receiving hydroxyurea. Acquired von Willebrand syndrome was identified in 17 of the 84 screened patients (20%), but was not associated with any major bleeding complications. Non-melanoma skin cancers were reported in 51 patients (27%). Hydroxyurea-related fever occurred in nine of 149 patients (6%) who received hydroxyurea. Seventy-three patients (39%) experienced a total of 98 major thrombotic events, with the majority of these occurring prior to or within 3 months of the diagnosis. Cyclical thrombocytosis, acquired von Willebrand syndrome, aggressive non-melanoma skin cancers and other hydroxyurea-related complications are not infrequent in MPNs and have important clinical consequences for management.
URI: https://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/1273
DOI: 10.3109/10428194.2013.827788
Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/23879199
ISSN: 1026-8022
Publicaton type: Journal Article
Keywords: Cancer
Leukaemia
Leukemia
Hematology
Haematology
Appears in Collections:Haematology

Show full item record

Page view(s)

6
checked on Feb 2, 2023

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.