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Title: Humoral immune failure defined by immunoglobulin class and immunoglobulin G subclass deficiency is associated with shorter treatment-free and overall survival in Chronic Lymphocytic Leukaemia
Authors: Forsyth, Cecily J ;Crassini, K.R.;Zhang, E.;Balendran, S.;Freeman, J.A.;Best, O.G.;Mackinlay, N.J.;Han, P.;Stevenson, W.S.;Mulligan, S.P.
Affliation: Central Coast Local Health District
Gosford Hospital
Issue Date: Apr-2018
Source: 181(1):97-101
Journal title: British Journal of Haematology
Department: Haematology
Abstract: Immune dysfunction attributed to hypogammaglobulinaemia is common in chronic lymphocytic leukaemia (CLL) and infection is a major contributor to morbidity and mortality. A higher incidence of multiple immunoglobulin and immunoglobulin G (IgG) subclass deficiency was associated with more advanced disease (P < 0.001 and P < 0.001, respectively) in a cohort of 147 CLL patients. Multiple immunoglobulin and IgG subclass deficiency were significantly associated with shorter treatment-free survival (TFS) (P < 0.001 and P = 0.006, respectively). The association between disease stage and immune dysfunction demonstrated by these data suggest aspects of immune deficiency correlate with disease severity and may be associated with shorter TFS in CLL.
DOI: 10.1111/bjh.15146
ISSN: 0007-1048
Publicaton type: Journal Article
Keywords: Haematology
Appears in Collections:Haematology

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