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|Title:||Humoral immune failure defined by immunoglobulin class and immunoglobulin G subclass deficiency is associated with shorter treatment-free and overall survival in Chronic Lymphocytic Leukaemia||Authors:||Forsyth, Cecily J ;Crassini, K.R.;Zhang, E.;Balendran, S.;Freeman, J.A.;Best, O.G.;Mackinlay, N.J.;Han, P.;Stevenson, W.S.;Mulligan, S.P.||Affliation:||Central Coast Local Health District
|Issue Date:||Apr-2018||Source:||181(1):97-101||Journal title:||British Journal of Haematology||Department:||Haematology||Abstract:||Immune dysfunction attributed to hypogammaglobulinaemia is common in chronic lymphocytic leukaemia (CLL) and infection is a major contributor to morbidity and mortality. A higher incidence of multiple immunoglobulin and immunoglobulin G (IgG) subclass deficiency was associated with more advanced disease (P < 0.001 and P < 0.001, respectively) in a cohort of 147 CLL patients. Multiple immunoglobulin and IgG subclass deficiency were significantly associated with shorter treatment-free survival (TFS) (P < 0.001 and P = 0.006, respectively). The association between disease stage and immune dysfunction demonstrated by these data suggest aspects of immune deficiency correlate with disease severity and may be associated with shorter TFS in CLL.||URI:||https://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/1283||DOI:||10.1111/bjh.15146||Pubmed:||https://www.ncbi.nlm.nih.gov/pubmed/29468645||ISSN:||0007-1048||Publicaton type:||Journal Article||Keywords:||Haematology
|Appears in Collections:||Haematology|
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