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https://hdl.handle.net/1/1372| Title: | Abnormal dicentric chromosome with co-amplification of sequences from chromosomes 11 and 19: a novel rearrangement in a patient with myelodysplastic syndrome transforming to acute myeloid leukemia | Authors: | Forsyth, Cecily J ;Smith, A.;Heaps, L.S.;Sharma, P.;Jarvis, A. | Issue Date: | Oct-2001 | Source: | Volume 130, Issue 1, pp. 29 - 32 | Journal title: | Cancer Genetics and Cytogenetics | Abstract: | A 66-year-old man with a myelodysplastic syndrome transforming to acute myeloid leukemia showed a complex abnormal karyotype on bone marrow aspirate. An unbalanced dicentric translocation with a very long der(11) long arm-dic(11;19)(q25;p13.4)-was present. Fluorescence in situ hybridization studies utilised paints for chromosomes 11 and 19 as well as the locus specific probe MLL, localised to 11q23. The abnormal chromosome 11q contained 6 copies of intact MLL and 6 copies of chromosome 19 (unidentified) sequences. To our knowledge, gene co-amplification of chromosomes 11 and 19 sequences has not been reported before. | URI: | https://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/1372 | Pubmed: | https://www.ncbi.nlm.nih.gov/pubmed/11672770 | ISSN: | 0165-4608 | Publicaton type: | Journal Article | Keywords: | Haematology Hematology Leukaemia Leukemia |
Study or Trial: | Case Series and Case Reports |
| Appears in Collections: | Haematology |
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