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Title: Abnormal dicentric chromosome with co-amplification of sequences from chromosomes 11 and 19: a novel rearrangement in a patient with myelodysplastic syndrome transforming to acute myeloid leukemia
Authors: Forsyth, Cecily J ;Smith, A.;Heaps, L.S.;Sharma, P.;Jarvis, A.
Issue Date: Oct-2001
Source: Volume 130, Issue 1, pp. 29 - 32
Journal title: Cancer Genetics and Cytogenetics
Abstract: A 66-year-old man with a myelodysplastic syndrome transforming to acute myeloid leukemia showed a complex abnormal karyotype on bone marrow aspirate. An unbalanced dicentric translocation with a very long der(11) long arm-dic(11;19)(q25;p13.4)-was present. Fluorescence in situ hybridization studies utilised paints for chromosomes 11 and 19 as well as the locus specific probe MLL, localised to 11q23. The abnormal chromosome 11q contained 6 copies of intact MLL and 6 copies of chromosome 19 (unidentified) sequences. To our knowledge, gene co-amplification of chromosomes 11 and 19 sequences has not been reported before.
ISSN: 0165-4608
Publicaton type: Journal Article
Keywords: Haematology
Study or Trial: Case Series and Case Reports
Appears in Collections:Haematology

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