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|Title:||Abnormal dicentric chromosome with co-amplification of sequences from chromosomes 11 and 19: a novel rearrangement in a patient with myelodysplastic syndrome transforming to acute myeloid leukemia||Authors:||Forsyth, Cecily J ;Smith, A.;Heaps, L.S.;Sharma, P.;Jarvis, A.||Issue Date:||Oct-2001||Source:||Volume 130, Issue 1, pp. 29 - 32||Journal title:||Cancer Genetics and Cytogenetics||Abstract:||A 66-year-old man with a myelodysplastic syndrome transforming to acute myeloid leukemia showed a complex abnormal karyotype on bone marrow aspirate. An unbalanced dicentric translocation with a very long der(11) long arm-dic(11;19)(q25;p13.4)-was present. Fluorescence in situ hybridization studies utilised paints for chromosomes 11 and 19 as well as the locus specific probe MLL, localised to 11q23. The abnormal chromosome 11q contained 6 copies of intact MLL and 6 copies of chromosome 19 (unidentified) sequences. To our knowledge, gene co-amplification of chromosomes 11 and 19 sequences has not been reported before.||URI:||https://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/1372||Pubmed:||https://www.ncbi.nlm.nih.gov/pubmed/11672770||ISSN:||0165-4608||Publicaton type:||Journal Article||Keywords:||Haematology
|Study or Trial:||Case Series and Case Reports|
|Appears in Collections:||Haematology|
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