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Title: Dopamine dysregulation syndrome in non-Parkinson's disease patients: a systematic review
Authors: Cartoon, Jodi ;Ramalingam, Jothi 
Affliation: Central Coast Local Health District
Gosford Hospital
Issue Date: Apr-2019
Source: 27(5):456-461
Journal title: Australasian Psychiatry
Department: Psychiatry
Abstract: OBJECTIVES: To explore the presence of dopamine dysregulation syndrome in non-Parkinson's disease patients receiving dopamine replacement therapy. METHODS: Electronic searches were conducted of Medline, Embase, PsycINFO and PreMedline to capture articles related to dopamine misuse or factitious disorder combined with the presence of dopamine replacement therapy or a non-Parkinson's disease population. In total, 430 articles were reviewed and studies that addressed dopamine dysregulation syndrome in non-Parkinson's disease patients were included. RESULTS: Nine case reports were identified. CONCLUSIONS: The pathophysiology underlying dopamine dysregulation syndrome has been thoroughly explored with numerous mechanisms posited. What remains unclear is whether dopamine dysregulation syndrome is a phenomenon specific to Parkinson's disease, as indicated in the proposed diagnostic criteria. A more useful predictor of susceptibility to dopamine dysregulation syndrome may be temperamental traits such as novelty seeking and impulsivity, which overlap with predisposing factors for an addiction disorder.
DOI: 10.1177/1039856219839476
ISSN: 1039-8562
Publicaton type: Journal Article
Keywords: Neurology
Appears in Collections:Health Service Research

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