Please use this identifier to cite or link to this item: https://hdl.handle.net/1/1596
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dc.contributor.authorJayamanne, Dasantha-
dc.contributor.authorWong, Matthew-
dc.contributor.authorBack, Michael-
dc.contributor.otherBack, E.-
dc.contributor.otherKastelan, M.-
dc.contributor.otherKhasraw, M.-
dc.contributor.otherBrown, C.-
dc.contributor.otherWheeler, H.-
dc.date.accessioned2019-08-23T02:42:10Zen
dc.date.available2019-08-23T02:42:10Zen
dc.date.issued2019-06-
dc.identifier.citation125(19):3457-3466en
dc.identifier.issn1097-0142en
dc.identifier.urihttps://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/1596en
dc.description.abstractBACKGROUND: Patients with anaplastic glioma (AG) harboring an isocitrate dehydrogenase mutation have potential durable survival after intensity-modulated radiotherapy (IMRT) and chemotherapy. Understanding long-term functioning, and the factors that have an impact on later effects, is important for decision making. METHODS: Consecutive patients with AG who received IMRT were reviewed with regard to 6 survivorship domains, including Eastern Cooperative Oncology Group (ECOG) performance status, Medical Research Council (MRC) neurological status, late toxicity, comorbidity, functional status (employment/driving), and psychosocial events. Assessments were performed at baseline before RT; at month +6; and at years +1, +3, and +5 after RT. The primary endpoints were ECOG at year +3 and employment at year +3. RESULTS: A total of 146 patients were included, with a median follow-up of 5.1 years. The 6-year overall survival rate was 78.7% (95% CI, 71.1%-87.0%). Baseline ECOG performance status was 0 to 1 in 82.2% of patients but improved at year +1 (95.7%) and year +3 (97.2%). Employment rates at year +3 and year +5 were 70.1% and 76.5%, respectively, compared with 61.6% at baseline. Worse ECOG performance status at year +3 was related to the anaplastic astrocytoma subtype (P = .001), delayed RT (P = .081), multiple craniotomies performed before RT (P = .002), worse ECOG performance status before RT (P < .001), worse MRC neurological status before RT (P < .001), seizures (P = .038), neurocognitive disturbance (P < .001), and the presence of recurrent disease (P = .004). Absent or impaired employment at year +3 was found to be related to older age (P = .007), delayed timing of RT (P = .023), multiple craniotomies prior to RT (P = .005), worse ECOG performance status before RT (P < .001), worse MRC neurological status before RT (P < .001), and neurocognitive disturbance (P < .001). CONCLUSIONS: Patients with AG with an isocitrate dehydrogenase mutation have the potential for prolonged survival. Functional status appears to be good in patients who are free of disease progression at 3 to 5 years after IMRT, with >95% of patients having high ECOG performance status and >75% being employed.en
dc.description.sponsorshipCentral Coast Cancer Centreen
dc.description.sponsorshipRadiation Oncologyen
dc.subjectCanceren
dc.subjectRadiotherapyen
dc.titleReflecting on survivorship outcomes to aid initial decision making in patients treated for IDH-mutated anaplastic gliomaen
dc.typeJournal Articleen
dc.identifier.doi10.1002/cncr.32352en
dc.description.pubmedurihttps://www.ncbi.nlm.nih.gov/pubmed/31251406en
dc.description.affiliatesCentral Coast Local Health Districten
dc.description.affiliatesGosford Hospitalen
dc.description.affiliatesNorthern Sydney Central Coast Healthen
dc.identifier.journaltitleCanceren
dc.relation.orcidhttp://orcid.org/0000-0003-2363-8333en
dc.relation.orcidhttp://orcid.org/0000-0002-5363-3974en
dc.originaltypeTexten
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
crisitem.author.deptRadiation Oncology-
Appears in Collections:Oncology / Cancer
Radiology
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