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Title: Amisulpride deliberate self-poisoning causing severe cardiac toxicity including QT prolongation and torsades de pointes
Authors: O'Mullane, Phebe ;Isbister, G.K.;Murray, L.;John, S.;Hackett, L.P.;Haider, T.;Gosselin, S.;Daly, F.
Issue Date: Apr-2006
Source: Volume 184, Issue 7, pp. 354 - 356
Journal title: The Medical Journal of Australia
Abstract: Although clinical trials of the antipsychotic amisulpride revealed no cardiac adverse effects, four patients with severe cardiac toxicity after overdose were reported to Australian poisons information centres in 2004-2005. All four had QT prolongation over 500 ms, two had rate-dependent bundle branch block, two developed torsades de pointes, and one died after cardiac arrest. Pending further studies, we recommend electrocardiogram assessment until at least 16 h after amisulpride overdose and, if QT interval is prolonged, cardiac monitoring until the patient is clinically well and conduction intervals are normal.
ISSN: 0025-729x
Publicaton type: Journal Article
Keywords: Cardiology
Mental Health
Appears in Collections:Cardiology

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