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Title: Remedial effects of novel 2,3-disubstituted thiazolidin-4-ones in chemical mediated inflammation
Authors: Mathew, Geetha ;Mudgal, J.;Gowdra, V.S.;Nayak, P.G.;Reddy, N.D.;Namdeo, N.;Kumar, R.R.;Kantamaneni, C.;Chamallamudi, M.R.;Nampurath, G.K.
Issue Date: Mar-2014
Source: March 2014, Volume 210, pp. 34 - 42
Journal title: Chemico-Biological Interactions
Abstract: Three thiazolidin-4-one derivatives were synthesized, purified and characterized by chromatographic and spectroscopic methods. In the in vitro assays, these compounds inhibited reactive oxygen species (ROS), nitrite and cytokine generation in RAW 264.7 murine macrophages and whole blood. These derivatives attenuated carrageenan-induced acute inflammation in rats. The most effective compound 4C possessed identical anti-inflammatory action at two doses (50 and 100 mg/kg). Further, the effect of compound 4C on locally induced inflammatory mediators was investigated in carrageenan-induced air pouch inflammation in rats. In this model, compound 4C inhibited the cytokines, tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 (systemic and local). Additionally, compound 4C was able to reduce locally elevated prostaglandin-E(2) (PGE(2)). Inhibition of leukocyte infiltration by compound 4C was correlated with reduced locally released myeloperoxidase (MPO). To conclude, compound 4C corrected the inflammatory condition by negative effect on cytokine (TNF-alpha, IL-6) network and prostaglandin-E(2) generation.
DOI: 10.1016/j.cbi.2013.12.012
ISSN: 0009-2797
Publicaton type: Journal Article
Keywords: Research
Appears in Collections:Health Service Research

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