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Title: Sleep and orexin: A new paradigm for understanding behavioural-variant frontotemporal dementia?
Authors: Hwang, Yun Tae ;Piguet, O.;Hodges, John R;Grunstein, R.;Burrell, J.R.
Affliation: Central Coast Local Health District
Gosford Hospital
Issue Date: Jul-2020
Source: 54:101361
Journal title: Sleep Medicine Reviews
Department: Neuroscience
Abstract: Behavioural variant frontotemporal dementia (bvFTD) is a complex and heterogeneous disorder with as yet unidentified unifying pathophysiological mechanism. There is emerging evidence that hypothalamic dysfunction, manifesting as disturbances in sleep and metabolism, is an integral component of neurodegeneration in bvFTD. Although sleep and metabolic disturbances and the behavioural abnormalities of bvFTD may appear disparate on the surface, there may be a common underlying hormonal mechanism involving orexin. Orexin is a hypothalamic neurotransmitter directly responsible for control of sleep and metabolism in healthy individuals and is implicated in many abnormal behaviours commonly seen in bvFTD - such as impulsive behaviour, hedonistic reinforcement and binge-consumption of ethanol. Further characterising orexin's role in pathophysiology of bvFTD could lead to a new paradigm for understanding this disease and may provide a new direction towards effective management and treatment.
DOI: 10.1016/j.smrv.2020.101361
ISSN: 1087-0792
Publicaton type: Journal Article
Keywords: Sleep
Appears in Collections:Health Service Research

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