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Title: Somatic mutational landscape of hereditary hematopoietic malignancies caused by germ line RUNX1, GATA2, and DDX41 variants
Authors: Homan, Claire C;Drazer, Michael W;Yu, Kai;Lawrence, David Michael;Feng, Jinghua;Arriola-Martinez, Luis Alberto;Pozsgai, Matthew J;McNeely, Kelsey E;Ha, Thuong Thi;Venugopal, Parvathy;Arts, Peer;King-Smith, Sarah;Cheah, Jesse Jc;Armstrong, Mark;Wang, Paul;Bödör, Csaba;Cantor, Alan B;Cazzola, Mario;Degelman, Erin S;DiNardo, Courtney D;Duployez, Nicolas;Favier, Rémi;Fröhling, Stefan;Rio-Machin, Ana;Klco, Jeffery M;Krämer, Alwin;Kurokawa, Mineo;Lee, Joanne;Malcovati, Luca;Morgan, Neil V;Georges, Natsoulis;Owen, Carolyn;Patel, Keyur P;Preudhomme, Claude;Raslova, Hana;Rienhoff, Hugh Young;Ripperger, Tim;Schulte, Rachael R;Tawana, Kiran;Velloso, Elvira;Benedict, Yan;Kim, Erika Mijin Kwon;Sood, Raman;Hsu, Amy P;Holland, Steven M;Phillips, Kerry;Poplawski, Nicola;Babic, Milena;Wei, Andrew H;Forsyth, Cecily J ;Mar Fan, Helen;Lewis, Ian;Cooney, Julian P;Susman, Rachel;Fox, Lucy C;Blombery, Piers;Singhal, Deepak;Hiwase, Devendra K;Phipson, Belinda;Schreiber, Andreas W;Hahn, Christopher N;Scott, Hamish S;Liu, Paul P;Godley, Lucy A;Brown, Anna L
Affliation: Central Coast Local Health District
Wyong Hospital
Issue Date: 5-Jul-2023
Source: Online ahead of print
Journal title: Blood Advances
Department: Haematology
Abstract: Individuals with germline variants associated with hereditary hematopoietic malignancies (HHMs) have a highly variable risk for leukemogenesis. Gaps in our understanding of pre-malignant states in HHMs have hampered efforts to design effective clinical surveillance programs, provide personalized pre-emptive treatments and inform appropriate counselling for patients. We used the largest known comparative international cohort of germline RUNX1, GATA2, or DDX41 variant carriers without and with hematopoietic malignancies (HMs) to identify patterns of genetic drivers that are unique to each HHM syndrome before and after leukemogenesis. These patterns included striking heterogeneity in rates of early-onset clonal hematopoiesis (CH), with a high prevalence of CH in RUNX1 and GATA2 variant carriers who did not have malignancies ("carriers-without HM"). We observed a paucity of CH in DDX41 carriers-without HM. In RUNX1 carriers-without HM with CH, we detected variants in TET2, PHF6, and, most frequently, BCOR. These genes were recurrently mutated in RUNX1-driven malignancies, suggesting CH is a direct precursor to malignancy in RUNX1-driven HHMs. Leukemogenesis in RUNX1 and DDX41 carriers was often driven by second-hits in RUNX1 and DDX41, respectively. This study may inform the development of HHM-specific clinical trials and gene-specific approaches to clinical monitoring. For example, trials investigating the potential benefits of monitoring DDX41 carriers-without HM for low-frequency second hits in DDX41 may now be beneficial. Similarly, trials monitoring carriers-without HM with RUNX1 germline variants for the acquisition of somatic variants in BCOR, PHF6, TET2, and second hits in RUNX1 are warranted.
DOI: 10.1182/bloodadvances.2023010045
Publicaton type: Journal Article
Keywords: Cancer
Appears in Collections:Haematology
Oncology / Cancer

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