Please use this identifier to cite or link to this item: https://hdl.handle.net/1/2740
Title: The complexities of managing a newborn with 6q24 transient neonatal diabetes mellitus: a case report
Authors: De Silva, Yannick;Birt, Stewart 
Affliation: Central Coast Local Health District
Gosford Hospital
Issue Date: 17-Sep-2024
Source: Online ahead of print
Journal title: Journal of pediatric Endocrinology & Metabolism : JPEM.
Department: Paediatrics
Abstract: This case report delves into the intricate management of a newborn with transient neonatal diabetes mellitus (TNDM), shedding light on the complexities and challenges in treatment decisions. Born prematurely with a low birth weight and a maternal background of gestational diabetes, the infant developed hyperglycaemia necessitating intravenous insulin therapy. Subsequent genetic testing confirmed 6q24-TNDM, due to the uniparental disomy of the whole of chromosome 6. Glibenclamide, a second-generation sulfonylurea, was cautiously introduced but discontinued due to adverse effects. Despite post-meal hyperglycaemia, blood glucose levels stabilised over subsequent weeks. Regular follow-ups demonstrated appropriate growth and development and the resolution of diabetes. This unique case highlights the need for multidisciplinary collaboration, tailored treatment strategies, and vigilant monitoring in managing 6q24-TNDM.
URI: https://hdl.handle.net/1/2740
DOI: 10.1515/jpem-2024-0258
Pubmed: https://pubmed.ncbi.nlm.nih.gov/39279438
Publicaton type: Journal Article
Keywords: Paediatrics
Pediatrics
Newborn and Infant
Study or Trial: Case Series and Case Reports
Appears in Collections:Obstetrics / Paediatrics

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