Please use this identifier to cite or link to this item: https://hdl.handle.net/1/1544
Title: Assessing the burden of pregnancy-associated malaria under changing transmission settings
Authors: Bamford, Paul ;Recker, M.;Bouma, M.J.;Gupta, S.;Dobson, A.P.
Issue Date: Oct-2009
Source: Volume 8, Article No. 245
Journal title: Malaria Journal
Abstract: BACKGROUND: The clinical presentation of pregnancy-associated malaria, or PAM, depends crucially on the particular epidemiological settings. This can potentially lead to an underestimation of its overall burden on the female population, especially in regions prone to epidemic outbreaks and where malaria transmission is generally low. METHODS: Here, by re-examining historical data, it is demonstrated how excess female mortality can be used to evaluate the burden of PAM. A simple mathematical model is then developed to highlight the contrasting signatures of PAM within the endemicity spectrum and to show how PAM is influenced by the intensity and stability of transmission. RESULTS: Both the data and the model show that maternal malaria has a huge impact on the female population. This is particularly pronounced in low-transmission settings during epidemic outbreaks where excess female mortality/morbidity can by far exceed that of a similar endemic setting. CONCLUSION: The results presented here call for active intervention measures not only in highly endemic regions but also, or in particular, in areas where malaria transmission is low and seasonal.
URI: https://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/1544
DOI: 10.1186/1475-2875-8-245
Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/19863792
ISSN: 1475-2875
Publicaton type: Journal Article
Keywords: Pregnancy
Infection
Appears in Collections:Obstetrics / Paediatrics

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