Please use this identifier to cite or link to this item: https://hdl.handle.net/1/1575
Title: Pharmacodynamic effects of a novel prokinetic 5-HT receptor agonist, ATI-7505, in humans
Authors: Ford, Tom ;Camilleri, M.;Vazquez-Roque, M.I.;Burton, D.;McKinzie, S.;Zinsmeister, A.R.;Druzgala, P.
Issue Date: Jan-2007
Source: Volume 19, Issue 1, pp. 30 - 38
Journal title: Neurogastroenterology and Motility
Abstract: ATI-7505, an investigational 5-HT(4) receptor agonist, was designed to have similar activity as cisapride without the cardiac adverse effects, i.e. without QT prolongation. In addition, ATI-7505 is not metabolized by CYP450. The aim of the study was to assess the effect of ATI-7505 on gastrointestinal (GI) and colonic transit in healthy humans. A randomized, parallel-group, double-blind, placebo-controlled study evaluated effects of 9-day treatment with ATI-7505 (3, 10 or 20 mg t.i.d.) on scintigraphic GI and colonic transit in healthy volunteers (12 per group). Primary endpoints were gastric-emptying (GE) T(1/2), colonic geometric centre (GC) at 24 h and ascending colon (AC) emptying T(1/2). Daily stool diaries were kept. Analysis of covariance assessed overall treatment group differences, followed by post hoc unadjusted pairwise comparisons. There were borderline overall treatment effects (decrease) on GE T(1/2) (P = 0.154); the 20 mg t.i.d. of ATI-7505-accelerated GE vs placebo (P = 0.038). ATI-7505 increased colonic transit (GC24, P = 0.031) with fastest transit at 10 mg t.i.d. vs placebo (P = 0.065). ATI-7505 accelerated AC emptying T(1/2) (overall P = 0.075) with 10 mg dose vs placebo (P = 0.042). There was looser stool (Bristol stool form scale, overall P = 0.056) with the 10 and 20 mg t.i.d. doses. No safety issues were identified. ATI-7505 accelerates overall colonic transit and tends to accelerate GE and AC emptying and loosen stool consistency.
URI: https://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/1575
DOI: 10.1111/j.1365-2982.2006.00865.x
Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/17187586
ISSN: 1350-1925
Publicaton type: Journal Article
Keywords: Gastrointestinal Tract
Drug Therapy
Study or Trial: Randomized Controlled Clinical Trial/Controlled Clinical Trial
Appears in Collections:Cardiology

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