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Title: Beneficial effects of increasing monounsaturated fat intake in adolescents with type 1 diabetes
Authors: King, Jennie ;Donaghue, K.C.;Pena, M.M.;Chan, A.K.F.;Blades, Barbara ;Storlien, L.H.;Silink, M.
Issue Date: Jun-2000
Source: Volume 48, Issue 3, pp. 193 - 199
Journal title: Diabetes Research and Clinical Practice
Abstract: This study aimed to increase the monounsaturated fat content in the diet of outpatient adolescents with type 1 diabetes and to examine the metabolic effects after 12 weeks. Twenty-three adolescents were randomly allocated to either a high monounsaturated fat diet or a control diet. Their mean age was 16.9 (S.D. 2.1) years and median HbA1c was 9.1% [IQR 7.9–10.4%]. dietary targets were not reached judged by their 4-day food diaries. However, the whole study group had a significant increase in monounsaturated fat as indexed by red cell phospholipid fatty acids (RCFAs), with an increase of n-9 RCFAs from 14.9% [IQR: 14.5–21.7%] to 21.7% [IQR: 18.8–25.6%] (P=0.002). Changes in n-9 RCFAs were inversely related to changes in HbA1c (R2=0.26, P=0.02), such that a 10% increase in n-9 RCFAs corresponded to a 0.64% improvement (decrease) in HbA1c. Changes in n-9 RCFAs were also inversely related to changes in plasma total cholesterol (R2=0.38, P=0.002) and plasma LDL cholesterol (R2=0.21, P=0.03). These changes were not associated with changes in insulin dose, body weight or physical activity. Overall, the results demonstrate that a modest increase in the monounsaturated fat content of an adolescent diet has the potential to improve glycaemic control and lipid profile. © 2000 Elsevier Science Ireland Ltd. All rights reserved.
DOI: 10.1016/S0168-8227(00)00123-6
ISSN: 0168-8227
Publicaton type: Journal Article
Keywords: Nutrition
Study or Trial: Randomized Controlled Clinical Trial/Controlled Clinical Trial
Appears in Collections:Health Service Research

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