Please use this identifier to cite or link to this item:
|Title:||Concurrent carbogen and nicotinamide with radiation therapy in muscle invasive bladder cancer: A report on feasibility in the Australian setting||Authors:||Anzela, Anzela ;Min, M.;Knesl, M.;Buddle, N.;Azzopardi, M.;Hooshmand, R.;Barrett, S.;Notman, A.;Woolls, H.;Wilson, J.;Vignarajah, D.D.||Affliation:||Central Coast Local Health District
|Issue Date:||Jun-2021||Source:||65(6):768-777||Journal title:||Journal of Medical Imaging and Radiation Oncology||Department:||Central Coast Cancer Centre||Abstract:||INTRODUCTION: The incidence of bladder cancer increases with age, and elderly patients with muscle invasive bladder cancer (MIBC) are significantly undertreated. Bladder preservation trimodality therapy (BPTT) is an alternative to radical cystectomy in the curative setting. The use of concurrent carbogen and nicotinamide (CON) with radiation therapy (RT) as radiosensitisers have shown significant improvement in the overall survival and local relapse in the UK BCON Trial and is part of the standard of care for patients with MIBC in the UK. This is the first study in the Australian setting to demonstrate the feasibility in setting up a CON radiation oncology department. METHODS: Based on the UK BCON trial, circuit systems for carbogen gas delivery were set up in consultation with the anaesthetics and respiratory teams. TGA exemption was obtained for 98% oxygen and 2% carbon dioxide carbogen gas mixture and delivery apparatus for each patient. Seven patients with histological locally advanced bladder cancer were recruited into this study. RESULTS: The establishment of a CON department took approximately 24 months. Development of trial protocol was based on the equipment availability in Australia and proper transport, storage and handling of the equipment was guided by local occupational, health and safety (OHS) regulations. All patients received full of dose of CON. Increased urinary frequency, urgency and diarrhoea were the most commonly reported acute bladder and bowel toxicities. CONCLUSIONS: This is the first study in Australia to demonstrate the feasibility of concurrent CON with radiation therapy. It is a safe and cost-effective treatment that provides a new therapeutic option in the treatment of patients with MIBC, particularly those with limited treatment options.||URI:||https://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/1988||DOI:||10.1111/1754-9485.13265||Pubmed:||https://pubmed.ncbi.nlm.nih.gov/34196122/||ISSN:||1754-9477||Publicaton type:||Journal Article||Keywords:||Radiotherapy
|Appears in Collections:||Oncology / Cancer|
Show full item record
checked on Feb 5, 2023
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.