Please use this identifier to cite or link to this item: https://hdl.handle.net/1/2241
Title: Associations between Smoking and Alcohol and Follicular Lymphoma Incidence and Survival: A Family-Based Case-Control Study in Australia
Authors: Odutola, Michael K;van Leeuwen, Marina T;Turner, Jennifer;Bruinsma, Fiona;Seymour, John F;Prince, Henry M;Milliken, Samuel T;Trotman, Judith;Verner, Emma;Tiley, Campbell ;Roncolato, Fernando;Underhill, Craig R;Opat, Stephen S;Harvey, Michael;Hertzberg, Mark;Benke, Geza;Giles, Graham G;Vajdic, Claire M
Affliation: Central Coast Local Health District
Issue Date: 30-May-2022
Source: 14(11):2710
Journal title: Cancers
Department: Haematology
Abstract: The association between smoking and alcohol consumption and follicular lymphoma (FL) incidence and clinical outcome is uncertain. We conducted a population-based family case-control study (709 cases: 490 controls) in Australia. We assessed lifetime history of smoking and recent alcohol consumption and followed-up cases (median = 83 months). We examined associations with FL risk using unconditional logistic regression and with all-cause and FL-specific mortality of cases using Cox regression. FL risk was associated with ever smoking (OR = 1.38, 95%CI = 1.08-1.74), former smoking (OR = 1.36, 95%CI = 1.05-1.77), smoking initiation before age 17 (OR = 1.47, 95%CI = 1.06-2.05), the highest categories of cigarettes smoked per day (OR = 1.44, 95%CI = 1.04-2.01), smoking duration (OR = 1.53, 95%CI = 1.07-2.18) and pack-years (OR = 1.56, 95%CI = 1.10-2.22). For never smokers, FL risk increased for those exposed indoors to >2 smokers during childhood (OR = 1.84, 95%CI = 1.11-3.04). For cases, current smoking and the highest categories of smoking duration and lifetime cigarette exposure were associated with elevated all-cause mortality. The hazard ratio for current smoking and FL-specific mortality was 2.97 (95%CI = 0.91-9.72). We found no association between recent alcohol consumption and FL risk, all-cause or FL-specific mortality. Our study showed consistent evidence of an association between smoking and increased FL risk and possibly also FL-specific mortality. Strengthening anti-smoking policies and interventions may reduce the population burden of FL.
URI: https://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/2241
DOI: 10.3390/cancers14112710
Pubmed: https://pubmed.ncbi.nlm.nih.gov/35681690/
Publicaton type: Journal Article
Keywords: Lymphoma
Study or Trial: Case Control Studies
Appears in Collections:Haematology

Show full item record

Page view(s)

80
checked on Nov 22, 2024

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.