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Title: Associations between Smoking and Alcohol and Follicular Lymphoma Incidence and Survival: A Family-Based Case-Control Study in Australia
Authors: Odutola, Michael K;van Leeuwen, Marina T;Turner, Jennifer;Bruinsma, Fiona;Seymour, John F;Prince, Henry M;Milliken, Samuel T;Trotman, Judith;Verner, Emma;Tiley, Campbell ;Roncolato, Fernando;Underhill, Craig R;Opat, Stephen S;Harvey, Michael;Hertzberg, Mark;Benke, Geza;Giles, Graham G;Vajdic, Claire M
Affliation: Central Coast Local Health District
Issue Date: 30-May-2022
Source: 14(11):2710
Journal title: Cancers
Department: Haematology
Abstract: The association between smoking and alcohol consumption and follicular lymphoma (FL) incidence and clinical outcome is uncertain. We conducted a population-based family case-control study (709 cases: 490 controls) in Australia. We assessed lifetime history of smoking and recent alcohol consumption and followed-up cases (median = 83 months). We examined associations with FL risk using unconditional logistic regression and with all-cause and FL-specific mortality of cases using Cox regression. FL risk was associated with ever smoking (OR = 1.38, 95%CI = 1.08-1.74), former smoking (OR = 1.36, 95%CI = 1.05-1.77), smoking initiation before age 17 (OR = 1.47, 95%CI = 1.06-2.05), the highest categories of cigarettes smoked per day (OR = 1.44, 95%CI = 1.04-2.01), smoking duration (OR = 1.53, 95%CI = 1.07-2.18) and pack-years (OR = 1.56, 95%CI = 1.10-2.22). For never smokers, FL risk increased for those exposed indoors to >2 smokers during childhood (OR = 1.84, 95%CI = 1.11-3.04). For cases, current smoking and the highest categories of smoking duration and lifetime cigarette exposure were associated with elevated all-cause mortality. The hazard ratio for current smoking and FL-specific mortality was 2.97 (95%CI = 0.91-9.72). We found no association between recent alcohol consumption and FL risk, all-cause or FL-specific mortality. Our study showed consistent evidence of an association between smoking and increased FL risk and possibly also FL-specific mortality. Strengthening anti-smoking policies and interventions may reduce the population burden of FL.
DOI: 10.3390/cancers14112710
Publicaton type: Journal Article
Keywords: Lymphoma
Study or Trial: Case Control Studies
Appears in Collections:Haematology

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