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Title: Lead Intoxication in an Anuric Patient: Management by Intraperitoneal EDTA
Authors: Roger, Simon D ;Crimmins, Denis ;Yiannikas, C.;Harris, D.C.
Issue Date: Dec-1990
Source: Volume 20, Issue 6, pp. 814-817
Journal title: Australian and New Zealand Journal of Medicine
Abstract: Treatment of lead intoxication with intravenous ethylene-diamine-tetra-acetic acid (EDTA) depends on the urinary excretion of chelated lead. This route of excretion was absent in a 48-year-old patient with childhood lead exposure and end stage renal failure who developed encephalopathy and a rapidly progressive neuropathy thought to be due to acute lead intoxication. Diagnosis was confirmed by lead chelation with EDTA and neurophysiological studies. EDTA was added by the patient to her chronic ambulatory peritoneal dialysis (CAPD) fluid each week and chelated lead excreted in the dialysate. Intraperitoneal administration of EDTA was 70% as efficient in removing lead as intravenous administration. Four months of home chelation therapy was associated with resolution of the encephalopathy but no improvement in the peripheral neuropathy.
ISSN: 0004-8291
Publicaton type: Journal Article
Keywords: Dialysis
Kidney Disease
Drug Therapy
Appears in Collections:Renal Medicine

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