Please use this identifier to cite or link to this item: https://hdl.handle.net/1/245
Title: A randomised single-blind study to improve health-related quality of life by treating Anaemia of chronic kidney disease with Aranesp(R) (darbepoetin alfa) in older people: STIMULATE
Authors: Roger, Simon D ;Jassal, Sarbjit ;Woodward, Michael ;Soroka, Steven ;McMahon, L.P.
Issue Date: Feb-2014
Source: Volume 46, Issue 2, pp. 469-475
Journal title: International Urology and Nephrology
Abstract: BACKGROUND: The prevalence of chronic kidney disease (CKD) increases with age, and the risk of significant anaemia increases as renal function declines. The objectives of this study were to assess the effect of darbepoetin alfa administration on health-related quality of life (HRQOL) through treatment for anaemia in older patients with CKD. METHODS: In this multicentre, randomised, placebo-controlled trial, older patients (aged >/= 70 years) with CKD (Stages 3-5, predialysis) and haemoglobin (Hb) < 11.0 g/dL were randomised to darbepoetin alfa (n = 28) or placebo (n = 23). HRQOL was measured using a number of instruments including Short Form-36 (SF-36) and Functional Assessment of Cancer Therapy-Anaemia (FACT-An). RESULTS: The primary endpoint, mean SF-36 Vitality Score at Week 24, was comparable between the darbepoetin alfa (51.4 [95 % CI 48.0, 54.9]) and placebo (46.7 [40.9, 52.5]) groups. Darbepoetin alfa-treated patients experienced statistically significant improvements in some SF-36 and FACT-An Subscale Scores. Mean Hb was higher with darbepoetin alfa (12.5 [12.1, 12.9] g/dL) than with placebo (10.5 [10.1, 11.0] g/dL). The safety profiles were comparable between the treatment groups. The study was limited by only 20 % of the planned patient recruitment being achieved. CONCLUSIONS: Darbepoetin alfa increased Hb and, within study limitations, suggested that improvements in some HRQOL domains in older CKD patients with anaemia may be achieved with more physiological haemoglobin.
URI: https://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/245
DOI: 10.1007/s11255-013-0512-1
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23982766
ISSN: 1573-2584
Publicaton type: Journal Article
Keywords: Kidney Disease
Aged
Anaemia
Anemia
Study or Trial: Randomized Controlled Clinical Trial/Controlled Clinical Trial
Appears in Collections:Renal Medicine

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