Please use this identifier to cite or link to this item: https://hdl.handle.net/1/257
Title: Contribution of Anaemia to progression of renal disease: A debate
Authors: Rossert, Jerome ;McClellan, William ;Roger, Simon D ;Verbeelen, Dierik ;Horl, Walter 
Issue Date: Jan-2002
Source: Volume 17, Supplement 1, pp. 60-66
Journal title: Nephrology Dialysis Transplantation
Abstract: It is hypothesized that anaemia contributes to the progression of renal disease via hypoxia and oxidative stress. These effects may stimulate the production of extracellular matrix by fibroblasts, increasing interstitial fibrosis and leading to tubular destruction. Recombinant human erythropoietin (r-HuEPO, epoetin) has antioxidative and anti-apoptotic properties, though these effects have yet to be demonstrated in renal cells. In theory, epoetin treatment might slow the progression of renal failure, not only by correcting anaemia but also via direct effects on tubular and vascular cell survival. Alternative hypotheses suggest, however, that epoetin could have negative effects on the kidney because of its vasoconstrictive action, which is independent of haemoglobin levels. Retrospective and prospective clinical studies clearly show that epoetin does not accelerate progression of renal disease, provided that blood pressure is well controlled. Some studies suggest that epoetin slows the progression of renal failure, although this remains a controversial issue, as all these studies have methodological limitations. Larger randomized controlled trials and meta-analysis of the existing trials are required to establish whether treatment of anaemia with epoetin can indeed slow the progression of renal disease.
Description: Open Source: http://ndt.oxfordjournals.org/content/17/suppl_1/60.short
URI: https://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/257
DOI: 10.1093/ndt/17.suppl_1.60
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11812915
ISSN: 0931-0509
Publicaton type: Journal Article
Keywords: Kidney Disease
Anaemia
Anemia
Appears in Collections:Renal Medicine

Show full item record

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.