Please use this identifier to cite or link to this item: https://hdl.handle.net/1/2735
Title: Manual Chest PRESSURE During Direct Current Cardioversion for Atrial Fibrillation: A Randomized Control Trial (PRESSURE-AF)
Authors: Ferreira, David;Mikhail, Philopatir ;Lim, Joyce;Ray, Max;Dwivedi, Jovita;Brienesse, Stephen;Butel-Simoes, Lloyd;Meere, William ;Bland, Adam ;Howden, Nicklas ;Malaty, Michael;Kunda, Mercy;Kelty, Amy ;McGee, Michael;Boyle, Andrew;Sverdlov, Aaron L;William, Maged ;Attia, John;Jackson, Nicholas;Morris, Gwilym;Barlow, Malcolm;Leitch, James;Collins, Nicholas;Ford, Tom ;Wilsmore, Bradley 
Affliation: Central Coast Local Health District
Gosford Hospital
Issue Date: 22-Jul-2024
Source: S2405-500X(24)00487-0
Journal title: JACC. Clinical electrophysiology
Department: Cardiology
Abstract: Direct current cardioversion is frequently used to return patients with atrial fibrillation (AF) to sinus rhythm. Chest pressure during cardioversion may improve the efficacy of cardioversion through decreasing transthoracic impedance and increasing cardiac energy delivery. This study aimed to assess the efficacy and safety of upfront chest pressure during direct current cardioversion for AF with anterior-posterior pad positioning. This was a multicenter, investigator-initiated, double-blinded, randomized clinical trial. Recruitment occurred from 2021 to 2023. Follow-up was until hospital discharge. Recruitment occurred across 3 centers in New South Wales, Australia. Inclusion criteria were age ≥18 years, referred for cardioversion for AF, and anticoagulation for 3 weeks or transesophageal echocardiography excluding left atrial appendage thrombus. Exclusion criteria were other arrhythmias requiring cardioversion, such as atrial flutter and atrial tachycardia. The intervention arm received chest pressure during cardioversion from the first shock. The primary efficacy outcome was total joules required per patient encounter. Secondary efficacy outcomes included first shock success, transthoracic impedance, cardioversion success, and sinus rhythm at 30 minutes post cardioversion. A total of 311 patients were randomized, 153 to control and 158 to intervention. There was no difference in total joules applied per encounter in the control arm vs intervention arm (355.0 ± 301 J vs 413.8 ± 347 J; P = 0.19). There was no difference in first shock success, total shocks provided, average impedance, and cardioversion success. This study does not support the routine application of chest pressure for direct current cardioversion in atrial fibrillation (PRESSURE-AF [Investigating the Efficacy of Chest Pressure for Direct Current Cardioversion in Atrial Fibrillation: A Randomized Controlled Trial]; ACTRN12620001028998).
URI: https://hdl.handle.net/1/2735
DOI: 10.1016/j.jacep.2024.05.037
Pubmed: https://pubmed.ncbi.nlm.nih.gov/39230541
Publicaton type: Journal Article
Keywords: Cardiology
Heart Disease
Study or Trial: Randomized Controlled Clinical Trial/Controlled Clinical Trial
Appears in Collections:Cardiology

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