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|Title:||Patients' perceptions of health-related quality of life during and after adjuvant radiotherapy for T1N0M0 breast cancer||Authors:||Sundaresan, Puma ;Sullivan, L.;Pendlebury, S.;Kirby, A.;Rodger, A.;Joseph, D.;Campbell, I.;Dhillon, H.M.;Stockler, M.R.||Issue Date:||Jan-2015||Source:||Volume 27, Issue 1, pp. 9 - 15||Journal title:||Clinical Oncology||Abstract:||AIMS: The effects of radiotherapy on health-related quality of life (HRQOL) may influence decisions about adjuvant radiotherapy after breast-conserving surgery. We sought women's ratings of HRQOL during and after radiotherapy. MATERIALS AND METHODS: Women completed HRQOL measures before, during and after adjuvant radiotherapy for node-negative, hormone receptor-positive breast cancers that were less than 2 cm in size. Acute and late toxicities were rated by clinicians. RESULTS: There were 161 participants with a median age of 58 years (range 34-82). Mean scores for most aspects of HRQOL worsened only slightly during radiotherapy and improved to baseline levels or better within a few months. The symptoms rated as most distressing were: difficulty sleeping (29%), fatigue (23%), breast discolouration (21%), uncertainty about the future (18%), feeling sad or depressed (18%), feeling anxious or worried (19%). Most rated their experience as better (39%) or much better (28%) than expected. Grade 3 toxicities were rare (5% acute, 1% late) with no grade 4 toxicities. CONCLUSIONS: Radiotherapy was associated with transient and generally mild impairments in a few aspects of HRQOL. Concerns about adverse effects on HRQOL should not weigh heavily on decisions about adjuvant breast radiotherapy.||URI:||https://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/1406||DOI:||10.1016/j.clon.2014.09.007||Pubmed:||https://www.ncbi.nlm.nih.gov/pubmed/25267304||ISSN:||1433-2981||Publicaton type:||Journal Article||Keywords:||Cancer
|Appears in Collections:||Oncology / Cancer|
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