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Title: Therapy-induced drug resistance in a human leukemia line (LALW-2). A clinically relevant model
Authors: Tiley, Campbell ;White, L.;Haber, M.;Brian, M.J.;Norris, M.D.;Trickett, A.;Sosula, L.;Stewart, B.W.
Issue Date: Jun-1989
Source: Volume 63, Issue 11, pp. 2103 - 2010
Journal title: Cancer
Abstract: A human leukemic T-cell line, LALW-2, established by xenografting in nude mice, has been maintained through 14 serial passages. The cells display consistent morphologic features, immunophenotype, and karyotypic aberrations (including an 11;14 translocation) and exhibit rearrangement of the T-cell receptor beta-chain gene. The growth rate of LALW-2 xenografts was differentially affected by drugs administered to host mice, the cells being resistant to cytotoxic agents (particularly methotrexate and doxorubicin) used in treatment of the donor patient. In short-term in vitro culture, LALW-2 cells exhibited extreme resistance to methotrexate and were also resistant to vincristine, vinblastine, dactinomycin, and doxorubicin. The findings differ from those obtained with laboratory-derived methotrexate or multidrug-resistant cell lines. The response of LALW-2 cells, in both the nude mouse model and in vitro, is consistent with acquisition of drug-resistance as a result of clinical treatment.
ISSN: 0008-543x
Publicaton type: Journal Article
Keywords: Leukaemia
Appears in Collections:Oncology / Cancer

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