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Title: Investigating the efficacy of chest pressure for direct current cardioversion in atrial fibrillation: a randomised control trial protocol (Pressure-AF)
Authors: Mikhail, Philopatir ;Ferreira, D.;McGee, M.;Boyle, A.;Sverdlov, A.;William, Maged ;Jackson, N.;Barlow, M.;Leitch, J.;Ford, Tom ;Collins, N.;Wilsmore, B
Affliation: Central Coast Local Health District
Gosford Hospital
The University of Newcastle
Issue Date: 8-Sep-2021
Source: 8(2):e001739
Journal title: Open Heart
Department: Cardiology
Abstract: INTRODUCTION: Atrial fibrillation (AF) is the most common sustained arrhythmia worldwide. Direct current cardioversion is commonly used to restore sinus rhythm in patients with AF. Chest pressure may improve cardioversion success through decreasing transthoracic impedance and increasing cardiac energy delivery. We aim to assess the efficacy and safety of routine chest pressure with direct current cardioversion for AF. METHODS AND ANALYSIS: Multicentre, double blind (patient and outcome assessment), randomised clinical trial based in New South Wales, Australia. Patients will be randomised 1:1 to control and interventional arms. The control group will receive four sequential biphasic shocks of 150 J, 200 J, 360 J and 360 J with chest pressure on the last shock, until cardioversion success. The intervention group will receive the same shocks with chest pressure from the first defibrillation. Pads will be placed in an anteroposterior position. Success of cardioversion will be defined as sinus rhythm at 1 min after shock. The primary outcome will be total energy provided. Secondary outcomes will be success of first shock to achieve cardioversion, transthoracic impedance and sinus rhythm at post cardioversion ECG. ETHICS AND DISSEMINATION: Ethics approval has been confirmed at all participating sites via the Research Ethics Governance Information System. The trial has been registered on the Australia New Zealand Clinical Trials Registry (ACTRN12620001028998). De-identified patient level data will be available to reputable researchers who provide sound analysis proposals.
DOI: 10.1136/openhrt-2021-001739
ISSN: 2053-3624
Publicaton type: Journal Article
Keywords: Cardiology
Appears in Collections:Cardiology

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