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Title: STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol.
Authors: Sturm, Jonathan ;Carey, Leeanne M;Crewther, Sheila;Salvado, Olivier;Linden, Thomas;Connelly, Alan;Wilson, William;Howells, David W;Churilov, Leonid;Ma, H.;Tse, Tamara;Rose, Stephen;Palmer, Susan;Bougeat, Pierrick;Campbell, B.C.;Christensen, S.;Macaulay, S. Lance;Favaloro, J.;O'Collins, Victoria;McBride, Simon;Bates, Susan;Cowley, Elise;Dewey, H.M.;Wijeratne, Tessa;Gerraty, Richard;Phan, Thanh G;Yan, Bernard;Parsons, M.W.;Bladin, C.F.;Barber, P.A.;Read, Stephen;Wong, Andrew;Lee, Andrew;Kleinig, T.;Hankey, G.J.;Blacker, David;Markus, R.;Leyden, James;Krause, Martin;Grimley, Rohan;Mahant, N.;Jannes, J.;Davis, Stephen M;Donnan, G.A.
Affliation: Florey Institute of Neuroscience and Mental Health
La Trobe University
Commonwealth Scientific and Industrial Research Organisation (CSIRO)
Gothenburg University, Sweden
Monash Medical Centre
University of Melbourne
Melbourne Brain Centre
Austin Health, Victoria
Western Health, Melbourne
Epworth Healthcare, Melbourne
John Hunter Hospital, Newcastle, NSW
The University of Newcastle
Eastern Health, Melbourne
Auckland City Hospital, New Zealand
Royal Brisbane and Women's Hospital, Queensland
Flinders Medical Centre, Adelaide
Royal Adelaide Hospital, South Australia
The University of Western Australia
Sir Charles Gardiner Hospital, Perth
St Vincent's Hospital, Sydney
Lyell McEwin Hospital, Adelaide
Royal North Shore Hospital, Sydney
Nambour General Hospital, Queensland
Westmead Hospital, Sydney
The Queen Elizabeth Hospital, South Australia
Issue Date: Jun-2015
Source: Volume 10, Issue 4, pp.636-644
Journal title: International Journal of Stroke
Abstract: RATIONALE: Stroke and poststroke depression are common and have a profound and ongoing impact on an individual's quality of life. However, reliable biological correlates of poststroke depression and functional outcome have not been well established in humans. AIMS: Our aim is to identify biological factors, molecular and imaging, associated with poststroke depression and recovery that may be used to guide more targeted interventions. DESIGN: In a longitudinal cohort study of 200 stroke survivors, the START-STroke imAging pRevention and Treatment cohort, we will examine the relationship between gene expression, regulator proteins, depression, and functional outcome. Stroke survivors will be investigated at baseline, 24h, three-days, three-months, and 12 months poststroke for blood-based biological associates and at days 3-7, three-months, and 12 months for depression and functional outcomes. A sub-group (n=100), the PrePARE: Prediction and Prevention to Achieve optimal Recovery Endpoints after stroke cohort, will also be investigated for functional and structural changes in putative depression-related brain networks and for additional cognition and activity participation outcomes. Stroke severity, diet, and lifestyle factors that may influence depression will be monitored. The impact of depression on stroke outcomes and participation in previous life activities will be quantified. STUDY OUTCOMES: Clinical significance lies in the identification of biological factors associated with functional outcome to guide prevention and inform personalized and targeted treatments. Evidence of associations between depression, gene expression and regulator proteins, functional and structural brain changes, lifestyle and functional outcome will provide new insights for mechanism-based models of poststroke depression.
DOI: 10.1111/ijs.12190
ISSN: 1747-4949
Publicaton type: Journal Article
Keywords: Stroke
Study or Trial: Cohort Study
Appears in Collections:Neurology

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