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Title: Understanding the Revised Fourth Edition of the World Health Organization Classification of Tumours of the Central Nervous System (2016) for Clinical Decision-making: A Guide for Oncologists Managing Patients with Glioma
Authors: Back, Michael ;Jayamanne, Dasantha ;Rodriguez, M.;Khasraw, M.;Lee, A.;Wheeler, H.
Affliation: Central Coast Local Health District
Gosford Hospital
Issue Date: Sep-2018
Source: 30(9):556-562
Journal title: Clinical oncology (Royal College of Radiologists (Great Britain))
Department: Radiation Oncology
Central Coast Cancer Centre
Abstract: The recognition of specific molecular prognostic factors has altered the management of primary brain tumours over the past decade. These factors have allowed stratification of morphologically similar tumours into different prognostic groups and are now also being used to determine clinical trial eligibility. Many of these factors have been included in the revised fourth edition of the World Health Organization (WHO) Classification of Tumours of the Central Nervous System, released in May 2016. This revised edition places greater emphasis on molecular testing and, for certain tumour types, molecular testing is required for diagnosis. Many pathology departments have also adopted the four-tiered report format suggested in the Haarlem guidelines, and provide a final 'integrated diagnosis' incorporating a morphological diagnosis, the WHO grade and molecular findings. Pathologists need to perform and report these molecular tests in a timeframe that is relevant for clinical decision-making. Clinicians need to understand and incorporate these changes into their daily practice, as they have direct effects on both the type and intent of therapeutic interventions.
DOI: 10.1016/j.clon.2018.06.005
ISSN: 1433-2981
Publicaton type: Journal Article
Keywords: Cancer
Appears in Collections:Oncology / Cancer

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