Please use this identifier to cite or link to this item: https://hdl.handle.net/1/1265
Title: Optimising Outcomes for Glioblastoma through Subspecialisation in a Regional Cancer Centre
Authors: Back, Michael F ;Jayamanne, Dasantha ;Wong, Matthew ;Cove, N.;Wheeler, H.;Khasraw, M.;Guo, L.;Back, J.
Affliation: Central Coast Local Health District
Gosford Hospital
Issue Date: Oct-2018
Source: 8(10):186
Journal title: Brain Sciences
Department: Central Coast Cancer Centre
Radiation Oncology
Abstract: Delivery of highly sophisticated, and subspecialised, management protocols for glioblastoma in low volume rural and regional areas creates potential issues for equivalent quality of care. This study aims to demonstrate the impact on clinical quality indicators through the development of a novel model of care delivering an outsourced subspecialised neuro-oncology service in a regional centre compared with the large volume metropolitan centre. Three hundred and fifty-two patients with glioblastoma were managed under the European Organisation for Research and Treatment of Cancer and National Cancer Institute of Canada Clinical Trials Group (EORTC-NCIC) Protocol, and survival outcome was assessed in relation to potential prognostic factors and the geographical site of treatment, before and after opening of a regional cancer centre. The median overall survival was 17 months (95% CI: 15.5(-)18.5), with more favourable outcome with age less than 50 years (p < 0.001), near-total resection (p < 0.001), Eastern Cooperative Oncology Group (ECOG) Performance status 0, 1 (p < 0.001), and presence of O-6 methylguanine DNA methyltransferase (MGMT) methylation (p = 0.001). There was no difference in survival outcome for patients managed at the regional centre, compared with metropolitan centre (p = 0.35). Similarly, no difference was seen with clinical quality process indicators of clinical trial involvement, rates of repeat craniotomy, use of bevacizumab and re-irradiation. This model of neuro-oncology subspecialisation allowed equivalent outcomes to be achieved within a regional cancer centre compared to large volume metropolitan centre.
URI: https://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/1265
DOI: 10.3390/brainsci8100186
Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/30326653
ISSN: 2076-3425
Publicaton type: Journal Article
Keywords: Cancer
Neuropathology
Study or Trial: Clinical Trial
Appears in Collections:Oncology / Cancer

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