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Title: Folate nutritional genetics and risk for hypertension in an elderly population sample
Authors: Ng, Xiaowei ;Boyd, Lyndell ;Dufficy, Lisa ;Naumovski, Nenad ;Blades, Barbara ;Travers, Cheryl ;Lewis, Peter R ;Sturm, Jonathan ;Yates, Z.;Townley-Jones, Maureen ;Roach, Paul ;Veysey, Martin ;Lucock, M.
Issue Date: Feb-2009
Source: Volume 2, Issue 1, pp. 1-8
Journal title: Journal of Nutrigenetics and Nutrigenomics
Abstract: BACKGROUND/AIMS: 118 elderly participants (65-90 years) were assessed for any relationship between folate, related genes and hypertension. METHODS: Six B-vitamin-related SNPs were genotyped in 80 normotensive and 38 hypertensive subjects. RESULTS: Of six polymorphisms (677C>T-MTHFR, 1298A>C-MTHFR, 80G>A-RFC, 2756A>G-MS, 66A>G- MSR, 19bpDHFR and 1561C>T-GCPII), only 677C>T-MTHFR was a significant risk for hypertension: OR 1.89; 95% CI 1.07-3.32 (chi2 p = 0.038). Additionally, hypertensive subjects had a significantly lower intake of dietary folate than normotensive individuals (p = 0.0221), although this did not markedly alter blood metabolite levels. Several significant linear associations between dietary folate and related blood metabolites were found in normotensive subjects (p < 0.001 for Hcy, red cell and serum folate) and were as predicted on an a priori basis -- generally weaker associations existed in hypertensive subjects (p < 0.05 for serum folate). This was true for data examined collectively or by genotype. Multiple-regression analysis for diastolic or systolic blood pressure showed significant interaction for gender and folate intake (p = 0.014 and 0.019, respectively). In both cases this interaction occurred only in females, with higher folate intake associated with decreased blood pressure. Regressing diastolic blood pressure and 677C>T-MTHFR genotype showed significance (males; p = 0.032) and borderline significance (all subjects). CONCLUSION: Dietary folate and 677C>T-MTHFR genotype may modify blood pressure.
DOI: 10.1159/000160079
ISSN: 1661-6499
Publicaton type: Journal Article
Keywords: Aged
Appears in Collections:Gastroenterology

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